The Science Behind NoToxMD


Discover clinically proven, innovative skincare that delivers visible, lasting results with NoToxMD

A Groundbreaking Approach to Wrinkle Reduction

At NoToxMD, we are proud to lead the way in scientifically proven skincare solutions with the first ever independently validated wrinkle-reducing clinical trial conducted on real people. Our commitment to delivering trustworthy, effective treatments is demonstrated through rigorous testing and validation processes.

Pioneering Clinical Validation

The remarkable efficacy of NoToxMD was meticulously assessed in a groundbreaking study whose findings were published in the prestigious Journal of Clinical and Cosmetic Dermatology. This study utilised advanced 3D skin imaging technology to precisely measure the effects of our treatment over time. The results? A clinical and statistically significant reduction in the appearance of wrinkles beginning as early as 3 weeks, with progressively stronger results observed at 6 weeks and even more profound improvements at 12 weeks.

Rigorous Standards and Global Recognition

Our innovative approach has not only been recognised in clinical settings but has also met the rigorous standards required for inclusion in an international trial. NoToxMD has been officially approved by the Australian New Zealand Clinical Trials Registry (ANZCTR) to participate in a World Health Organization (WHO) trial. This trial pits No-Tox™ against Tretinoin, a well-known pharmaceutical-grade treatment, underscoring our product's significant potential in anti-aging skincare.

Commitment to Excellence

These achievements reflect our dedication to excellence and our promise to provide products that are not only safe but also supremely effective. By grounding our product development in solid scientific research, we ensure that NoToxMD offers real, visible results that you can trust. Whether you’re looking to reduce the appearance of wrinkles or enhance your overall skin health, NoToxMD stands as a leader in age-defying skincare, combining the best of nature with the rigors of science for unparalleled performance.


Developed in New Zealand by globally acclaimed Professor of Skin biomedical engineering, Dr Sharad Paul.